PIs: Andrea Olschewski & Nagaraj Chandran
Focus: Our research group focuses on the molecular and functional regulation of pulmonary blood vessels and on the causes and consequences of pulmonary vascular diseases. Particular emphasis is placed on metabolic alterations, the interaction of vascular cells with their microenvironment, and disrupted cell-to-cell communication—both in preclinical models and patient-oriented approaches. Our goal is to better understand regulatory mechanisms and identify novel therapeutic targets. Pulmonary vascular diseases can occur at any age but are becoming increasingly relevant in aging societies. Estimates suggest that up to 10% of people over the age of 65 are affected. However, about 80% of patients live in low- and middle-income countries, where the disease often occurs in association with congenital heart defects and diseases such as schistosomiasis or rheumatic fever—affecting a significantly younger population. Regardless of the underlying cause, pulmonary hypertension is associated with progressive clinical deterioration and a markedly increased risk of mortality.
Networks: Our group is internationally connected and collaborates closely with translational research networks, clinical partners and patient advocacy groups. We are actively involved in multiple research projects and maintain strong ties with basic science, clinical departments, and biomedical companies. This interdisciplinary approach helps bridge the gap between laboratory research and clinical application—accelerating the translation of innovative therapies into practice.
